ChloroquineV1, Main, Exploration, bibRecord, 000466

Repurposing Quinacrine against Ebola Virus Infection In Vivo

Identifieur interne : 000466 ( Main/Exploration ); précédent : 000465; suivant : 000467

Repurposing Quinacrine against Ebola Virus Infection In Vivo

Auteurs : Thomas R. Lane [États-Unis] ; Jason E. Comer [États-Unis] ; Alexander N. Freiberg [États-Unis] ; Peter B. Madrid [États-Unis] ; Sean Ekins [États-Unis]

Source :

Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2019.

RBID : PMC:6709481

Abstract

Quinacrine hydrochloride is a small-molecule, orally bioavailable drug that has been used clinically as an antimalarial and for many other applications. A machine learning model trained on Ebola virus (EBOV) screening data identified quinacrine as a potent (nanomolar) in vitro inhibitor.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709481

DOI: 10.1128/AAC.01142-19
PubMed: 31307979
PubMed Central: 6709481

Affiliations:

Le document en format XML

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Serveur d'exploration Chloroquine

Repurposing Quinacrine against Ebola Virus Infection In Vivo

Repurposing Quinacrine against Ebola Virus Infection In Vivo

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Abstract

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